Published June 4, 2023
| Version v1
Dataset
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Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1
Authors/Creators
- 1. Department of Organic Chemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
- 2. School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland
- 3. Department of Genetic Medicine and Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
- 4. Chemical Biology Mass Spectrometry Platform (CHEMBIOMS), Faculty of Sciences, University of Geneva, Geneva, Switzerland
Description
Raw experimental data for the manuscript entitled 'Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog Pathway Inhibitor-1'. This includes the data underlying all figures, DESeq2 files, modeling and MD simulations, and chemical compound characterization (NMR, LC-MS, HRMS). Also, the custom Matlab script to analyse cilium intensity from microscopy images is included (cilia-track_v4.0).
Files
cilia-track_v4.0.zip
Files
(3.9 GB)
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Additional details
Related works
- Is described by
- Preprint: 10.1101/2022.08.16.504103 (DOI)
Funding
- Swiss National Science Foundation
- Deciphering and Targeting the Cancer Ubiquitylome CRSII5_186405
- Swiss National Science Foundation
- Inhibitors of cilia and Hedgehog signaling: from phenotype to mechanistic understanding 310030_189246
- Swiss National Science Foundation
- Epigenome editing to study chromatin remodeling during brain development PCEFP3_194305