The role of polymorphic variants of IL17A and cytochrome P450 genes with Graves' disease
Authors/Creators
- 1. Samarkand State Medical University
- 2. Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan
- 3. Tashkent State Dental Institute
Description
Objective: To study the distribution of allele and genotype frequencies of the polymorphic region G-197A (rs2275913) of the IL-17A gene and A6986G (rs776746) of the CYP3A5 gene in patients with Graves' disease and establish the contribution to the development of the disease.
Methods: The main group consisted of 97 patients with Graves' disease. The surveyed group consisted of individuals observed at the Department of Endocrinology of the Samarkand State Medical University. The study control group included 66 donors without thyroid pathology.
Results: In this study, we studied the distribution of allele and genotype frequencies of the polymorphic variant G-197A (rs2275913) of the IL-17A gene in patients with DTG. As can be seen from our results, the risk marker for the development of DTG is the A allele and the homozygous AA genotype (12.37% and 3.03%, respectively; OR = 4.518; 95% CI: 0.977 > 4.518 > 20.899; χ2 = 4.365 (p =0.03669)).
Conclusions. Thus, a significant increase in the A197 allele confirms the involvement of systemic inflammatory reactions in the pathogenesis of such a disease as diffuse toxic goiter.
Keywords: Diffuse toxic goiter, polymorphism, immune system, gene.
Objective: To study the distribution of allele and genotype frequencies of the polymorphic region G-197A (rs2275913) of the IL-17A gene and A6986G (rs776746) of the CYP3A5 gene in patients with Graves' disease and establish the contribution to the development of the disease.
Methods: The main group consisted of 97 patients with Graves' disease. The surveyed group consisted of individuals observed at the Department of Endocrinology of the Samarkand State Medical University. The study control group included 66 donors without thyroid pathology.
Results: In this study, we studied the distribution of allele and genotype frequencies of the polymorphic variant G-197A (rs2275913) of the IL-17A gene in patients with DTG. As can be seen from our results, the risk marker for the development of DTG is the A allele and the homozygous AA genotype (12.37% and 3.03%, respectively; OR = 4.518; 95% CI: 0.977 > 4.518 > 20.899; χ2 = 4.365 (p =0.03669)).
Conclusions. Thus, a significant increase in the A197 allele confirms the involvement of systemic inflammatory reactions in the pathogenesis of such a disease as diffuse toxic goiter.