The Role of 4G Allele in Plasminogen Activator Inhibitor-1 (rs1799889) Gene as Biomarker for Thrombophilic States among Patients with Type 2 Diabetes

The molecular diagnosis of the 4G allele and their level are good enough to evaluate the impairment of fibrinolysis in patients with type 2 DM. Furthermore, the patients with type 2 DM positive for the 4G allele must be given antithrombotic drugs like aspirin at least as the first-line protection from thrombus formation, especially in cardiovascular events because when the platelet is active release about 90% of the PAI-1 Ag.