Published September 5, 2022
| Version v1
Dataset
Open
Functional precision profiling reveals non-mutational rewiring of kinase signaling networks in colorectal cancer
Authors/Creators
- Plattner Christina1
- Lamberti Giorgia1
- Blattmann Peter2
- Kirchmair Alexander1
- Rieder Dietmar1
- Loncova Zuzana1
- Sturm Gregor1
- Scheidl Stefan3
- Ijsselsteijn Marieke4
- Fotakis Georgios1
- Noureen Asma1
- Lisandrelli Rebecca1
- Böck Nina1
- Nemati Niloofar1
- Krogsdam Anne1
- Daum Sophia5
- Finotello Francesca6
- Somarakis Antonios7
- Schäfer Alexander2
- Wilflingseder Doris8
- Gonzalez Acera Miguel9
- Öfner-Velano Dietmar3
- Huber Lukas A.10
- Clevers Hans11
- Becker Christoph9
- Farin Henner F.12
- Greten Florian R.12
- Aebersold Ruedi2
- da Cunha Carvalho de Miranda Noel Filipe4
- Trajanoski Zlatko1
- 1. Biocenter, Institute of Bioinformatics, Medical University of Innsbruck, Austria
- 2. Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Switzerland
- 3. Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Austria
- 4. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
- 5. Department of Internal Medicine V (Hematology and Oncology), Medical University of Innsbruck, Austria
- 6. Institute of Molecular Biology & Digital Science Center (DiSC), University of Innsbruck, Austria
- 7. Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands
- 8. Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria
- 9. Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany
- 10. Biocenter, Institute of Cell Biology, Medical University of Innsbruck, Austria
- 11. Hubrecht Institute, Utrecht, The Netherlands
- 12. Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus Frankfurt/Main, Germany
Description
Multi-omics profiling of colorectal cancer (CRC) patients and associated patient-derived organoids. Tumor organoids were characterized in steady-state and perturbed using kinase inhibitors.
Files
exomeseq.zip
Files
(4.8 GB)
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