Problems of Distribution and Pathophysiology of Gastroesophageal Reflux Disease

ABSTRACT: This article provides an overview of the literature data on the problem of the prevalence of gastroesophageal reflux disease. Some pathophysiological aspects of this pathology are analyzed. The authors conclude that gastroesophageal reflux disease is a common clinical problem that affects millions of people around the world, according to some reports, up to 25–30% of the adult population is affected by it. Patients are recognized by both classic and atypical symptoms. GERD is associated with lifestyle factors, in particular obesity and tobacco smoking, which also threatens overall health.