Published August 8, 2022 | Version v1
Dataset Restricted

Loss of Serpina1 in mice leads to altered gene expression in inflammatory and metabolic pathways

Authors/Creators

  • 1. Department of Respiratory Medicine, Platform Bioinformatics, Member of the German Center for Lung Research(DZL), Biomedical Research school in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, 30625 Hannover, Germany
  • 2. Functional genomics unit, rare diseases research institute, Carlos III health institute, Majadahonda(Madrid), Spain
  • 3. Division of Experimental Pneumology, Member of the German Center for Lung Research (DZL), Biomedical Research in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, 30625 Hannover, Germany
  • 4. Department of Respiratory Medicine, Molecular Pneumology, Member of German Center for Lung Research(DZL), Biomedical Research school in Endstage and Obstructive Lung Disease (BREATH), Hannover Medical School, 30625 Hannover, Germany

Description

This is the data relating to Livers taken from age- and sex-matched at 8 to 14 weeks of age C57BL/6 wild-type (WT) and Serpina1 knockout mice (KO), lacking all 5 serpin A1 a-e paralogues expressed in mice. Total RNA was isolated and performed RNA-sequencing and transcriptome analysis. The dataset contains the counts matrix for the mice samples mapped to the genes using HTSeq.

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