Evaluation of SARS-CoV-2 Total Antibodies After Two Doses of Coronavac in Healthcare Workers: Retrospective and Observational Study

Objevtive: During the pandemic process, physical distance, quarantine and isolation measures have been effective in limiting the number of infected people in the short term. However, special drugs and vaccines are required to be effective in the treatment and protection of COVID-19. In our study, it was aimed to compare antibody levels after inactivated Coronavac vaccine.

Methods:Our study included those who received two doses of CoronaVac vaccine from our hospital's healthcare workers. Blood antibody levels measured four weeks after the second dose of vaccine were compared according to age, gender, and units studied. Our study is a retrospective and observational study.

Results: A total of 491 healthcare employees were included in the study. Although no significant relations were detected between the total antibody levels, age, and gender, the antibody levels were significantly higher in those who had COVID-19 infection (P < 0.001). When the antibody levels of healthcare workers with COVID 19 infection are compared according to the units studied; the antibody levels of those working in risky units were statistically significantly higher than those working in these units. (P < 0.001)

Conclusions: The findings in our study showed that natural immunity supported by vaccination is more valuable than acquired immunity in terms of COVID-19.