Calcium homeostasis plays an important role in the progression of kidney damage and calcium deposits in the kidneysespecially in patients with malabsorption syndrome (MAS).
The resear chaimed to evaluate calcium homeostasis in kidney damage and calcium deposits in the kidneysinpatientswith MAS.
Methods.In this study, 109 kidney damage patients with MAS were enrolled. The patients were divided into 4 groups according to the CKD stage and the presence of MAS. Group I included 27 patients with kidney damage without MAS; Group II consisted of 28 patients with kidney damage and MAS; Group ІІІ (n = 26) and Group ІV (n = 28) included patients with kidney damage without and with MAS and calcium deposits in the kidneys, respectively. According to the morphological study of in vivo biopsies of the small intestinal mucosa, mild and moderate morphological changes were observed among all patients. The levels of calcium, phosphorus, parathyroid hormone, osteocalcin, and calcitonin in the blood, as well as urinary calcium levels, were detected.
Results. Pathological changes in calcium metabolism were observed among kidney damage patients with MAS and calcium deposits in the kidneys. These verity of calcium homeostasisd is orders was more evident among patients with calcium deposits in the kidneys and MAS. Urinary calcium levels were reduced in the patients of Groups III and IV. No changes were detected in phosphorus levels. Changes in parathyroid hormone and osteocalcinare caused primarily by combined renal pathology with impaired renal calciumabsorption.
Conclusion. MAS and calcium deposits in the kidneys patients leads to deep violations of calcium homeostasis resulting in rapid kidney damage progression and bone tissue violation.
Notes
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