ESTIMATION OF SERUM CRP,FERRITIN,D-DIMER,LACTATE DEHYDROGENASE IN COVID 19 PATIENTS
- 1. Associate Professor, Department of Biochemistry Government Medical College, Kadapa.
- 2. Associate professor, Department of Biochemistry, Andhra Medical College, Visakhapatnam.
- 3. Assistant Professor, Department of Biochemistry Guntur, Medical College, Guntur.
- 4. Assistant Professor, Department of Biochemistry Kurnool Medical College, Kurnool.
Description
Background: Severe COVID-19 illness is associated with intense inflammation, leading to high rates of thrombotic complications that increase morbidity and mortality . New laboratory tests capable of differentiating between severe and non-severe cases and appropriate management of COVID-19.
Aims and Objective: Aim to investigate the association between several biomarkers, including serum C-reactive protein (CRP), Lactate Dehydrogenase, D-dimer, and serum ferritin, and COVID-19 severity.
Methodology: The study was conducted during September 2020-Dec-2021 among Covid patients confirmed by RT-PCR and admitted to Government general hospital.LDH was estimated in semi-auto analyzer by UVkinetic method and serum Ferritin, CRP, D-dimer was estimated by Immunoturbidometric method.
Results: Amongst 1200 SARS-CoV-2 patients, Elevated CRP levels were seen in 88 percent of patients, D-Dimer in 94 percent of patients, Ferritin in 83 percent of patients, LDH in 93 percentof patients.
Discussion: Elevated serum CRP, D-dimer, and serum ferritin levels were associated withan increased poor outcome that comprises mortality, severe COVID-19, ARDS, and the need for ICU care in patients with COVID-19.
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