BREAST CANCER DEVELOPMENT

Abstract

Breast malignancy is a burdensome illness in the lives of women and communities globally. One in eight women in the world today stands a risk of developing breast cancer as compared to men who are at one in a thousand breast cancer risks. Most breast cancer cases are linked to breast somatic cells mutations acquirable during one’s lifetime. In the hereditary scenario, there are specific genetic factors that are involved and determine the inherited breast cancer risk and are attributed to inherited BRCA2 BRCA1 genes mutations whereas breast malignancy risk that’s not inherited have been linked to mutations in the ATM, STK11, CDH1, PTEN, TP53, PALB2 and CHEK2 and have been established to confer the risk of developing malignancy. Understanding the functional significance of hereditary mutations is important in informing the prevention of breast cancer and inform treatment strategies and this paper intends to inform this understanding.