Published June 21, 2022 | Version v1
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Engineered nanomaterial-relevant AOPs; network creation and identification of key nodes for adverse outcomes

  • 1. National Research Centre for the Working Environment, Copenhagen, Denmark
  • 2. Department of Environmental Engineering, Technical University of Denmark
  • 3. Research Center for Environmental Health (GmbH), Neuherberg, Germany; German Center for Lung Research (DZL), Giessen, Germany; Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum München - German, Oberschleißheim, Germany
  • 4. Department of the Environment, National Institute for Agricultural and Food Research and Technology (INIA-CSIC), Carretera de la Coruña, Madrid, Spain
  • 5. National Research Centre for the Working Environment, Copenhagen, Denmark; National Food Institute, Technical University of Denmark, Kgs.Lyngby, Denmark

Description

Adverse Outcome Pathways (AOPs) are a useful framework for organizing and presenting scientific data related to toxicological processes. As a step in the progress towards developing New Approach Methodologies (NAM) in the EU project HARMLESS, partners identified, compiled and organized existing and tentative AOPs relevant for engineered nanomaterial (ENM) induced adverse outcomes (AOs) to human health and ecology.

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Funding

HARMLESS – Advanced High Aspect Ratio and Multicomponent materials: towards comprehensive intelLigent tEsting and Safe by design Strategies 953183
European Commission