Structural and Kinetic Characteristics of Metatetrahydroxy-phenylchlorine Photosensitizer Complexes with Stimuli Dependent Nanocarriers

ABSTRACT

Photodynamic therapy (PDT) is a form of therapy that uses light along with special chemicals known as photosensitizers (PS) to treat cancer and many other diseases [1]. The effectiveness of PDT depends on the photophysical and spectral properties of the photosensitizer, the presence of a high quantum yield of reactive oxygen species (ROS) generation [2]. also, the outcome of PDT is largely determined by the pharmacodynamic properties of PS. The main intermediary in PDT is singlet oxygen. As its lifetime is short, its ability to diffuse into cells is limited to 10-55 nm Thus, photodynamic damage to biological structures is observed in a small area around the PS [3]. Therefore, photosensitizer delivery to cellular and tissue targets and its localization in them is important for PDT. Currently, one way of developing photodynamic therapy is through the use of special photosensitizer delivery systems, which increase the selectivity of PS delivery. Examples of such an approach are the use of nanostructured and supramolecular complexes of PS with nanoparticles, polymers, cyclodextrins, etc. [4].