Aminoquinoline/Antimalarial Binding to Fluid Lipid Assemblies Depends on Electron Density on Quinoline

Aminoquinolines (AQ) are the base compounds for antimalarials (AM) such as sitamaquine and primaquine phosphate. The mechanism of their biological activity is of prime interest [1-3]. As a result, in order to understand the molecular initiating events (MIEs) in the biological activity of AQ and AM compounds, it is essential as a first step to elucidate their interactions with biological membrane models [4]. Fig. 1(i) summarises two of the structures of the compounds investigated. The aim was to investigate the molecular descriptors which facilitated binding and subsequent damage to the lipid assemblies.