CINECA Federated Data Analytics for European Biobanks D5.1

In this report we describe the work done to develop the demonstration tool foreseen in CINECA Task T5.1, i.e. an integration of WP1-3 CINECA services to advance federated biobank search. Starting from the use cases defined during the preliminary stages of the project, the search process was first modeled through UML diagrams and then through mockups representing the future functionalities. The final user interface is pictured in the demonstration section which describes how CINECA services have been combined in an integrated use case to search biobanks and beyond biobanks, how the services will be integrated to serve all WP5 clinical use cases. Regarding the technical part, we describe the architecture of the system, as well as the strategies we have adopted either to access the data when they were exposed, or to store them locally when necessary. Further, we report in this document about the evaluation of the robustness and the search effectiveness of the implemented services.

Furthermore, in order to meet users' expectations regarding the types of findable data, an effort has been made to integrate information related to biobanks, in particular pre-analytical features. Pre-analytical data are describing how tissue and liquid samples are collected and processed. These data are important in determining the quality of biospecimens, i.e. variables of special interest for biobanks include time to storage, storage temperature, tubes and the like. Pre-analytical metadata describing tissue and liquid samples play a critical role in the quality of the biospecimens. We therefore prepared a synthetic dataset of pre-analytical data and developed a set of search services to find, access and ultimately visualize such data.