Published June 23, 2022 | Version v1
Dataset Open

Optimization and evaluation of a two-stage chromogenic tenase assay for measurement of emicizumab plasma levels

  • 1. Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany

Description

A two-stage chromogenic tenase assay allows specific measurement of emicizumab plasma levels over a broad concentration range (10 µg/ml to 100 µg/ml). The assay showed a reasonable agreement with one-stage clotting assy used for emicizumab quantificaition and can be applied on an automated coagulation analyzer, demonstrating its applicability within a routine laboratory setting.

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