Investigation for Anti Diabetic properties of Methanol Extracts prepared from Dried Apricot Kernels in Rats

ABSTRACT

Apricots are a sweet summer-fruit staple and a wonderful addition to your diabetes meal plan. One apricot has just 17 calories and 4 g of carbohydrates. Four fresh apricots equal one serving and provide more than 50 percent of your daily vitamin A requirement. These fruity jewels are also a good source of fiber. Modern medicine is best for treating any disease in the same way traditional medicine should also be encouraged cause the traditional medicine is available at cheaper cost and said to be without any side effects. To support this anti diabetic activity of apricot kernels is performed. In this study alloxan induced diabetic activity model rat was used. First the kernels are authenticated then extracted using methanol. The methanol extracts showed the presence of alkaloids, tannins, flavonoids etc. which maybe the reason for anti-diabetic activity. Alloxan forms an increased glucose levels that generates diabetes. Post treatment with apricot kernel extract produced significant decrease in glucose levels indicating the therapeutic effect of extract. The method for testing glucose levels in blood is done by glucometer On treatment a dose dependent (low dose-100mg/kg, high dose-200mg/kg.) decrease in glucose levels were observed. For the low dose, the glucose level decreased to 150.1±17mg/dl by 7^th day from 293.1±9.83mg/dl. For the high dose, the glucose level decreased to 125.7±20.7mg/dl by 7^th day from 280.5±42.4mg/dl. However, the standard medicine metformin at the dose of 450mg/kg showed better results with 112.3±2.4mg/dl. Even though the extracts results are lower than the standard with further research and purification of extracts better results can be achieved.

Keywords: Apricot kernel, diabetic activity, wistar rats etc.