Ubiquitin Proteins and the Orchestration of Transcription Factors Activity
Authors/Creators
- 1. Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Room 107, Ziyuan North Building, Xueyuan South Road No.80, Haidian District, Beijing 100081, China
- 2. Department of Plant Cell Biotechnology, Center of Plant Systems Biology and Biotechnology, 4000, Plovdiv, Bulgaria; Laboratory of Metabolomics, Department of Biotechnology, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 4000, Plovdiv, Bulgaria
Description
The ubiquitin proteasome system is a key pathway, regulating targeted proteins degradation.
A critical step is regulated by E3 ubiquitin ligases, which facilitates the transfer of ubiquitin
moieties to substrate proteins, leading proteins degradation via 26S proteasome.
However, the number of known ubiquitin dependent processes is still relatively small. Since
some stress-related transcription factors are usually essential under stress conditions, while
playing negative roles during normal growth, hence their protein levels need to be precisely
regulated. However, the mechanism of ubiquitin pathway, regulating transcription factors
stability has not been yet summarized. In this review, we attempted to outline the mechanism
of E3 ligases dependent transcription factors degradation and discuss the comprehensive
role of E3 ligases in phytohormone signaling.
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