Evaluation of Nephroprotective Effect of Carica Papaya Root Extract in Paracetamol Induced Nephrotoxicity in Experimental Rats

The purpose of this study is to evaluate if a hydroalcoholic root extract of Carica papaya has any nephroprotective qualities in Wistar rats with paracetamol-induced nephrotoxicity (PCM). When used in excessive doses, paracetamol (PCM), an analgesic and antipyretic, can cause liver and kidney necrosis in humans and animals. The animals were put into four groups of six each. The purpose of this study was to look into the effects of Carica papaya hydroalcoholic extract [200 mg/kg and 400 mg/kg] on Paracetamol-induced nephrotoxicity. For 7 days, the first group was given distilled water as a control, while the other groups were given Paracetamol alone (750 mg/kg), Paracetamol+200 mg/kg extract, and Paracetamol+400 mg/kg extract. Treatment with HACP root extract at doses of 200mg/kg and 400mg/kg prevented kidney damage caused by Paracetamol and free radical-induced kidney damage, as well as a significant decrease in weight of kidney, blood urea level, blood creatinine level, urinary glucose level, and urinary potassium level, as well as an increase in body weight, volume of urine, urine creatinine level, and total blood protein level. HACP substantially increased tissue GSH while decreasing lipid peroxidation. Histological observations confirmed that HACP therapy restored the degenerative effects of paracetamol. Finally, these above findings indicated that HACP has nephroprotective properties against kidney damage induced by Paracetamol.