Published May 4, 2022 | Version v1
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SYNTHESIS AND CHARACRTERIZATION OF 4 THIAZOLIDINEONE DERIVATIVES

  • 1. Department of Pharmaceutical Analysis and Chemistry, Sree Vidyanikethan College of Pharmacy, Tirupathi, Andrapradesh, India.
  • 2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AMITY University, Gwalior, India.

Description

Abstract: The thiazolidin-4-one core is unusually most valuable and has foreground in various clinically used medications. Most of the researchers are synthesized Thiazolidin-4-ones by using lot of conventional synthetic methods. These methods are more time consuming as well as worthful for the synthesis of compounds. Objective: Synthesis of novel substituted Thiazolidin-4-one analogues, Characterization of substituted thiazolidin-4-one analogues with chemico-spectral analysis by FT-IR, NMR and Mass spectroscopy. Method: DCC method (dicyclohexyl carbodimide). Result: Synthesized of novel substituted Thiazolidin-4-one analogues and characterized the substituted thiazolidin-4-one analogues by FT-IR, NMR and Mass spectroscopy. Conclusion: We synthesized novel thiazolidin-4-one by using conventional method like DCC method. Then the synthesized compounds were characterized by FT- IR, MASS, 1H NMR and 13C NMR. All the data of substituted Thiazolidin-4-one analogues were interpreted and tabulated.

Keywords: Thiazolidin-4-one; Dicyclohexyl Carbodimide; Mass spectroscopy; NMR spectroscopy; Furan; Fourier transform Infrared spectroscopy.

Title: SYNTHESIS AND CHARACRTERIZATION OF 4 THIAZOLIDINEONE DERIVATIVES

Author: Pandurangan Perumal, Murugesan V, Sai Ramya B, Divya reddy D, Gayathri P, Charan kumar V

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 9, Issue 3, May 2022 - June 2022

Page No: 10-17

Novelty Journals

Website: www.noveltyjournals.com

Published date: 04-May-2022

DOI: https://doi.org/10.5281/zenodo.6517058

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Novelty Journals, Website: www.noveltyjournals.com, International Journal of Novel Research in Life Sciences, ISSN 2394-966X

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References

  • [1] Stana A, Vodnar DC, Tamaian R, Pîrnău A, Vlase L, Ionuț I, Oniga O, Tiperciuc B. Design, synthesis and antifungal activity evaluation of new thiazolin-4-ones as potential lanosterol 14α- demethylase inhibitors. International journal of molecular sciences. 2017 Jan;18(1):177.
  • [2] Barreca ML, Balzarini J, Chimirri A, Clercq ED, Luca LD, Höltje HD, Höltje M, Monforte AM, Monforte P, Pannecouque C, Rao A. Design, synthesis, structure− activity relationships, and molecular modeling studies of 2, 3-diaryl-1, 3-thiazolidin-4-ones as potent anti-HIV agents. Journal of medicinal chemistry. 2002 Nov 21;45(24):5410-3.
  • [3] Chopra N, Kaur K, Kaur S. Assessment of Antimicrobial, Anti-Inflammatory Activity and Docking Study of Novel 2-(Arylimino)-5-(Indole-2-Yl-Methylidene)-1, 3-Thiazolidine-4-one Derivatives.
  • [4] Mital A, Prasad Burman R, Gour R, Singh Jhamb S, Singh Gill M. Synthesis, ADME Evaluation, and In Vitro Antimycobacterial Studies of a Novel Series of 2-Thiazolylimino-5- Arylidene-4-Thiazolidinone Derivatives. Anti-Infective Agents. 2017 Apr 1;15(1):38-44.
  • [5] Singh N, Tripathi AC, Tewari A, Kumar R, Saraf SK. Ulcerogenicity devoid novel non- steroidal anti-inflammatory agents (NSAIDS): syntheses, computational studies, and activity of 5-aryliden-2-imino-4-thiazolidinones. Medicinal Chemistry Research. 2015 May 1;24(5):1927-41. 6.Gaikwad SV, Bhake AB, Bhandarkar SE. 4-Thiazolidinone derivatives: synthesis and biological study. International Journal of Chem Sci. 2015;13(3).
  • [6] Küçükgüzel İ, Satılmış G, Gurukumar KR, Basu A, Tatar E, Nichols DB, Talele TT, Kaushik- Basu N. 2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase. European journal of medicinal chemistry. 2013 Nov 1;69:931-41.
  • [7] Murugesan V, Makwana N, Suryawanshi R, Saxena R, Tripathi R, Paranjape R, Kulkarni S, Katti SB. Rational design and synthesis of novel thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & medicinal chemistry. 2014 Jun 15;22(12):3159-70.
  • [8] Brahmbhatt H, Molnar M, Pavić V, Rastija V. Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study. Med Chem. 2019;15
  • [9] Solomon VR, Haq W, Srivastava K, Puri SK, Katti SB. Design and synthesis of 3-[(7-chloro-1- oxidoquinolin-4-ylamino)alkyl]-1,3-thiazolidin-4-ones as antimalarial agents. J Enzyme Inhib Med Chem. 2013;28(5)
  • [10] D'Ascenzio M, Bizzarri B, De Monte C, et al. Design, synthesis and biological characterization of thiazolidin-4-one derivatives as promising inhibitors of Toxoplasma gondii. Eur J Med Chem. 2014;
  • [11] Cunico W, Gomes CR, Vellasco Jr WT. Chemistry and biological activities of 1, 3-thiazolidin- 4-ones. Mini-Reviews in Organic Chemistry. 2008 Nov 1;5(4):336-44.
  • [12] Iyengar DS, Kamaiah J, Aanadalwar SM, Rangappa KS, Prasad JS. Synthesis and Crystal Structure of 2-(4-Chlorophenyl)-3-(4-phthalamide)-1, 3-thiazolidin-4-one. Analytical Sciences: X-ray Structure Analysis Online. 2006;22:x181-2.
  • [13] RB Gomes C, Moreth M, Facchinetti V, VN de Souza M, T Vellasco Junior W, Cristina da Silva Lourenco M, Cunico W. Synthesis and Antimycobacterial Activity of 2-aryl-3- (arylmethyl)-1, 3-thiazolidin-4-ones. Letters in Drug Design & Discovery. 2010 Jun 1;7(5):353-8.
  • [14] Ekinci A, Moncol J, Krishna V, Sriram D, ÖZADALI-SARI K. 5-Methyl-4-thiazolidinones: Synthesis and evaluation as antitubercular agents.
  • [15] Tripathi AC, Gupta SJ, Fatima GN, Sonar PK, Verma A, Saraf SK. 4-Thiazolidinones: the advancescontinue…. European Journal of Medicinal Chemistry. 2014 Jan 24;72:52-77.
  • [16] Singh T, Khobragade D. Synthesis and evaluation of thiazolidine-4-one for their antibacterial activity. JPSBR. 2014;4:110-3.
  • [17] Ramani V, Sureja D, Patel M, Sanghvi K, Shah A, Sailor G, Seth A. Synthesis, characterization and antimicrobial activity of 2, 3-disubstituted thiazolidin-4-one derivatives.
  • [18] KANKORIYA PK, HALVE A. Efficient Synthesis and Therapeutic Evaluation of 1, 3- Thiazolidin-4-ones as Potential Antifungal Agents.