RNA-seq data of HepG2 cultured in 2D or as organoids

Cancer cells cultured as organoids could better represent cancer cells grown in vivo and were shown to harbor increased stemness compared with cancer cells in 2D culture. Hep G2 cell line was used as parental cell line to establish a liver cancer organoid line. Hep G2 2D culture and organoid culture were subjected to bulk RNA-seq.