Anti-inflammatory activity of Sabicea brevipes Wernharm (Rubiaceae)
- 1. University of Nigeria, Nsukka, Nigeria
- 2. Department of Chemistry, M. S. Ramaiah Institute of Technology, Bengaluru, India
- 3. Department of Pharmaceutical Chemistry, Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Pune, India
- 4. Department of Chemistry, CHRIST (Deemed to be University), Bengaluru, India
- 5. Centurion University of Technology and Management, Bhubaneswar, India
- 6. Sandip Institute of Pharmaceutical Sciences, Nashik, India
- 7. MET Institute of Pharmacy, Bhujbal Knowledge City, Nashik, India
- 8. JMCT Institute of Pharmacy, Nashik, India
Description
Over the years, medicinal plants have been employed in the treatment of inflammation and related ailments. This study evaluated the anti-inflammatory potential of the aerial parts of S. brevipes. The extracts and fractions were further evaluated for anti-inflammatory activity in carrageenan-induced rat model at varying doses (200 and 400 mg/kg doses, orally) for 5 h of treatment. The result of the phytochemical screening showed the presence of alkaloids, terpenoids, glycosides, flavonoids and tannins in the aerial parts of the plant. The in vivo anti-inflammatory study exhibited inhibition of 42% and 44%, 47% and 36%, 33% and 31%, and 43% and 42% for methanol extract n-hexane fraction, ethyl acetate fraction, and methanol fraction, at 200 and 400 mg/kg doses, respectively. The positive control (diclofenac sodium) showed an inhibition value of 51% at 5 mg/kg dose. Finally, it is concluded that S. brevipes possesses anti-inflammatory potential which validates the enthnomedicinal claim of the plant.
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- Figure: 10.3897/pharmacia.69.e82311.figure1 (DOI)
- Figure: 10.3897/pharmacia.69.e82311.figure2 (DOI)