Conductometric Studies on the Dissociation Constants of Salicylic and Substituted Salicylic Acids in Methanol-Water Mixtures

Department of Chemistry, University of Kalyani, Nadia, West Bengal, India.

Manuscript received November 1976, revised 29 March 1977, accepted 3 June 1977

The pKa values of salicylic acid and 5-chloro- and 5-Bromo-salicylic acids in methanol+water mixtures (8 — 87.9 wt % of methanol) were determined using the conducto­metric method suggested by Gelb with a slight modification. The results have been further verified by Fouss-Kraus method. The limitations of the present state of knowledge of solution chemistry in accounting for the variations of the dissociation constants with solvent composition have been stressed.