Inflammasomes Role in the Pathogenesis of Periodontal Disease -A Review

Inflammasome is a multiprotein complex that consists of a PRR- an adaptor protein or ASC [apoptosisrelated speck-like protein containing a CARD (caspase activation and recruitment domain )] an active form of caspase-1.Active caspase-1 subsequently processes the leaderless proinflammatory cytokines pro L-1b and proIL-18, which are unconventionally secreted on caspase-1 cleavage. Therefore, inflammasome-mediated processing and secretion of pro-IL-1b and pro-IL-18 enables a rapid, yet tightly regulated and highly inducible proinflammatory response. In addition to cytokine secretion, inflammasome activation can also trigger an inflammatory cell death dubbed pyroptosis, which serves to blunt intracellular pathogen replication.