LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures
Description
For the Library of Integrated Network-based Cellu- lar Signatures (LINCS) project many gene expres- sion signatures using the L1000 technology have been produced. The L1000 technology is a cost- effective method to profile gene expression in large scale. LINCS Canvas Browser (LCB) is an interac- tive HTML5 web-based software application that fa- cilitates querying, browsing and interrogating many of the currently available LINCS L1000 data. LCB im- plements two compacted layered canvases, one to visualize clustered L1000 expression data, and the other to display enrichment analysis results using 30 different gene set libraries. Clicking on an ex- perimental condition highlights gene-sets enriched for the differentially expressed genes from the se- lected experiment. A search interface allows users to input gene lists and query them against over 100 000 conditions to find the top matching experiments. The tool integrates many resources for an unprece- dented potential for new discoveries in systems biol- ogy and systems pharmacology. The LCB application is available at http://www.maayanlab.net/LINCS/LCB. Customized versions will be made part of the http:// lincscloud.org and http://lincs.hms.harvard.edu web- sites.
Files
gku476.pdf
Files
(4.1 MB)
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