Chalcone Derivatives for Biological Potentials: A Strategy of Molecular Hybridization for Drug Design

Naturally and synthetically derived hybrid molecules are promising sources for new drug development due to their multiple modes of action and other advantages. Chalcone, two important classes of synthetic chemistry affording diverse pharmacological activities, make themselves ideal blocks for building a chalcone hybrid scaffold as a bioactive agent. Provoked by the promising medicinal applications of such hybrids, the scientific community has reported dozens of chalcone hybrids with a wide spectrum of biological properties including anticancer, antimicrobial, antimalarial, antioxidant, antianxiety and so on, through synthetic hybridization strategy. It is expected to assist medicinal chemists in the effective and successful development of chalcone hybrids. In view of these observations, we herein report the literature review of Chalcone hybrids which possessing antimicrobial, antioxidant and antianxiety potential.