Software for conducting allele-specific imbalance analyses and Regulome-Wide Association Studies (RWAS)

stratAS

A method for allele specific analyses across cell states and conditions. stratAS implements population-scale tests and predictive models for allele-specific activity (typically RNA or ATAC data). For more information see https://github.com/gusevlab/stratAS. 

FUSION

FUSION is a suite of tools for performing transcriptome-wide and regulome-wide association studies (TWAS and RWAS). FUSION builds predictive models of the genetic component of a functional/molecular phenotype and predicts and tests that component for association with disease using GWAS summary statistics. For more information see https://github.com/gusevlab/fusion_twas.

stratAS and FUSION were used to conduct analyses that are described in Grishin D. and Gusev A. Allelic imbalance of chromatin accessibility in cancer identifies candidate causal risk variants and their mechanisms (2022).