Dynamics of the tumor immune microenvironment during ne-oadjuvant chemotherapy of high-grade serous ovarian cancer
Authors/Creators
- 1. Department of Obstetrics and Gynecology, Institute of Women's Medical Life Science, Yonsei Universi-ty College of Medicine, Seoul, Republic of Korea
Description
Supplemental Figure S1: Comparison of immune cell fraction between pre- and post-NAC tumor samples by CIBERSORT.
Supplemental Figure S2: Forest plot showing the association between immune cell fractions, platinum sensitivity, and progression-free survival rate at 12 months.
(a) Platinum sensitivity. Platinum sensitivity was defined as recurrence 6 months after platinum-based chemotherapy, while platinum resistance was defined as recurrence within 6 months from platinum-based chemotherapy.
(b) Progression-free survival rate at 12 months.
Supplemental Figure S3: Gene set enrichment analysis of differentially expressed genes in pre- and post-NAC samples.
(a) JAK/STAT signaling pathway.
(b) Co-stimulation by the CD28 family.
Supplemental Table S1. Gene content in the TruSight Tumor 170 panel