Screening of Metal Complexes for Biological Activity. Part-IV: Synthesis of Pharmacologically and Microbiologically Active Thiocyanato and Oxalato Complexes of Fe2+, Co2+, Ni2+ and Cu2+ with 3-Phenylaminomethylbenzoxazolinone-2

Chemistry Department, Lucknow University, Luokuow-226 007

Chemistry Department, Sri Jai Narain Degree College, Lucknow
Manuscript received 9 July 1981, accepted 10 December 1981
Complexes of formula (MX2L2) where M=Fe²⁺, Co²⁺, Ni²⁺ and CU²⁺u; X=0.5 C₂ \(O_2^{4-}\)or SGN- and L=3-phenylamlaomethyl benzoxazolinone-2, have been prepared and characterised 0n the basis of analysis, conductance, magnetic moment, ir and diffuse refieetance spectral data. All the complexes were subjected to verions pharmacological tests viz., toxicity, effect on ONS and CVS, aatiinftammatory activity, aatlanaphylactic activity and diuresis. Complexes were also serened against E. \(hitotica\) and S  to evaluate their amoebieidal and bactericidal actions respectively. Fungitoxicity was studied against A \(nigar\), .A. \(flavous\) and F. \(solans\). Toxicity, anti-amoebic:, anti·bacterial and antifungal activities are inversely proportional to the radius or metal Jon.