R package BSDE

Single-cell RNAseq differential expression analysis for case-control studies using optimal transport. This is a nonparametric method for finding differentially expressed genes for case-control studies. Through the use of optimal transportation for aggregating distributions and computing their distances, our method overcomes the restrictive parametric assumptions imposed by standard mixed-effect-modeling approaches.

See https://github.com/mqzhanglab/BSDE