Published February 18, 2022
| Version 1.0.0
Dataset
Open
Differential gene expression data of commercial compounds used to assess the performance of human TeraTox assay
Description
The dataset supplements the publication `Optimization of the TeraTox assay for preclinical teratogenicity assessment`.
- 2022-02-18-TeraTox-commercial-logFC.gct: log2FC matrix of genes by compounds (in concentration ranges)
- 2022-02-18-TeraTox-commercial-pScore.gct: p-scores (log 10 transformed p-values with the sign of logFC) of genes by compounds
- 2022-02-18-TeraTox-commercial-featureData.txt: feature annotation in TSV format
- 2022-02-18-TeraTox-commercial-phenoData.txt: sample annotation in TSV format
- 2021-06-10-gcGeneFactorAnno-withPositiveCoefs.tsv: gene membership of germ-layer factors, with germ-layer annotation and average expression in copies per million (cpm).
Citation: Jaklin, Manuela, Jitao David Zhang, Nicole Schäfer, Nicole Clemann, Paul Barrow, Erich Küng, Lisa Sach-Peltason, Claudia McGinnis, Marcel Leist, and Stefan Kustermann. “Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment.” Toxicological Sciences 188, no. 1 (July 1, 2022): 17–33. https://doi.org/10.1093/toxsci/kfac046.
Files
2022-02-18-TeraTox-commercial-featureData.txt
Files
(9.7 MB)
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Additional details
Related works
- Is published in
- Journal article: 10.1093/toxsci/kfac046 (DOI)
- Is supplement to
- Preprint: 10.1101/2021.07.06.451364 (DOI)
Funding
- European Commission
- EU-ToxRisk - An Integrated European ‘Flagship’ Program Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century 681002
- European Commission
- RISK-HUNT3R - RISK assessment of chemicals integrating HUman centric Next generation Testing strategies promoting the 3Rs 964537
- European Commission
- TOX-Free - TOXicity assessment on neurons and cardiomyocytes by means of FluoRescence Emitting Electrodes 964518
- European Commission
- ENDpoiNTs - Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity 825759