Published January 25, 2022
| Version v1
Journal article
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NOVELSYNTHETIC METHOD FOROZENOXACIN
Authors/Creators
- 1. Discovery Chemistry Solutions, Aragen Life Sciences, Nacharam, Hyderabad, Telangana State, 500076, India.
- 2. Department of Inorganic and Analytical Chemistry, Andhra University, Visakhapatnam, Andhra Pradesh, 530003, India.
Description
A newsynthetic route has been developed for the total synthesis of ozenoxacin. In this route avoided toxic heavy metals and synthesised the key intermediate_7-bromo-1-cyclopropyl-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid by simply insertion of Cyclopropyl amine into 4-oxo-4H-chromene-3-carboxylic acid intermediate, Then the key intermediate carboxylic acidundergoesSuzuki coupling with boronated ester and deacetylation to afford ozenoxacin.
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