Published October 31, 1988
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Synthesis and Antimicrobial Activity of some New Thiazolo-, Quinoxalino-, Piperidino- and Naphthatriazino- coumarins
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Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt
Manuscript received 31 March 1987, revised 5 May 1988, accepted 8 July 1988
Various derivatives from 3-acetylcoumarin are prepared: aminothiazole (9), coumarilic acid ( ), piperidone (12), quinoxaline (14) and naphthatriazine (15). Active methylene compounds react with the arylidene (2a, b) to give the cyclohexanone derivatives (4a, b, respectively). SeO2 on reaction with 1 gives the α, β -diketon (13) which reacts with hydrazine to give 18. The antimicrobial activities of the products against different organisms are discussed.
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