Published February 11, 2022 | Version v1

Summary Statistics from "Genetically regulated gene expression and proteins revealed discordant effects" (LWAS of biomarker)

Authors/Creators

  • 1. IMISE, University Leipzig

Description

Summary statistics of 92 blood protein levels. The corresponding publication is currently under revision.

 The zipped txt file is tab-delimited and contains the following columns:

  • protein: protein name abbreviation
  • cytoband: genomic region
  • gene: gene name abbreviation
  • setting: either "combined" (adj. for sex & age) or sex-stratified ("males", "females"; adj. for age)
  • variant_id_hg19: SNP ID according to hg19
  • variant_id_hg38: SNP ID according to hg19
  • chr: chromosome
  • pos_hg19: base position according to hg19
  • pos_hg38: base position according to hg19
  • effect_allele: also known as counted allele in additive model
  • other_allele: not-counted allele
  • eaf: effect allele frequency
  • maf: minor allele frequency
  • info: imputation info score
  • n_samples: number of samples
  • beta: effect estimate
  • se: standard error
  • zscore: Z-statistic
  • pvalue: p-value
  • FDR: FDR by gene and setting
  • BBFDR: hierarchical FDR by setting
  • hierFDR: TRUE if SNP is significant after hierarchical FDR

Files

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