Antibody responses to BNT162b2 mRNA vaccine: infection-naïve individuals with abdominal obesity warrant attention.
- Alexis Elias Malavazos1
- Sara Basilico1
- Gianluca Iacobellis2
- Valentina Milani3
- Rosanna Cardani4
- Federico Boniardi1
- .Carola Dubini1
- Ilaria Prandon1
- Gloria Capitanio1
- Laura Valentina Renna4
- Sara Boveri3
- Roberta Rigolini5
- Matteo Carrara6
- Giovanni Spuria6
- Giovanni Spuria6
- Teresa Cuppone3
- Aurelia D'acquisto3
- Luca Carpinelli3
- Marta Sacchi7
- Lelio Morricone1
- Francesco Secchi8
- Elena Costa7
- Lorenzo Menicanti3
- Enzo Nisoli9
- Michele Carruba9
- Federico Ambrogi3
- Massimiliano Marco Corsi Romanelli10
- 1. Endocrinology Unit, Clinical Nutrition and Cardiovascular Prevention Service, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
- 2. Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami, FL, USA.
- 3. Scientific Directorate, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
- 4. Biobank BioCor, Service of Laboratory Medicine1-Clinical Pathology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
- 5. Operative Unit of Laboratory Medicine1-Clinical Pathology, Department of Pathology and Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
- 6. Residency program in Clinical Pathology and Clinical Biochemistry, University of Milano, Milan, Italy.
- 7. Service of Laboratory Medicine, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
- 8. Unit of Radiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
- 9. Department of Medical Biotechnology and Translational Medicine, Centre for Study and Research on Obesity, University of Milan, Milan, Italy.
- 10. Operative Unit of Laboratory Medicine1-Clinical Pathology, Department of Pathology and
Description
Dataset from Malavazos AE, Basilico S, Iacobellis G, Milani V, Cardani R, Boniardi F, Dubini C, Prandoni I, Capitanio G, Renna LV, Boveri S, Rigolini R, Carrara M, Spuria G, Cuppone T, D'acquisto A, Carpinelli L, Sacchi M, Morricone L, Secchi F, Costa E, Menicanti L, Nisoli E, Carruba M, Ambrogi F, Corsi Romanelli MM. Antibody responses to BNT162b2 mRNA vaccine: infection-naïve individuals with abdominal obesity warrant attention. Obesity (Silver Spring). 2021 Nov 30. doi: 10.1002/oby.23353. Epub ahead of print. PMID: 34850576.
Abstract
Objective: The excess of visceral adipose tissue might hinder and delay immune response. How people with abdominal obesity (AO) will respond to mRNA vaccines against SARS-CoV-2 is yet to be established. We evaluated SARS-CoV-2 specific antibody responses after the first and second dose of the BNT162b2 mRNA vaccine comparing the response of individuals with AO to those without, discerning between individuals with or without prior infection.
Methods: IgG neutralizing antibodies against the Trimeric-complex (IgG-TrimericS) were measured at four time points: at baseline, at day 21 after vaccine dose 1, at one and three months after dose 2. Nucleocapsid antibodies were assessed to detect prior SARS-CoV-2 infection. Waist circumference was measured to determine AO.
Results: Between the first and third month after vaccine dose 2, the drop in IgG-TrimericS levels was more remarkable in individuals with AO compared to those without AO (2.44 fold [95%CI: 2.22-2.63] vs 1.82 fold [95%CI: 1.69-1.92], respectively, p<0.001). Multivariable linear regression confirmed this result after inclusion of assessed confounders (p<0.001).
Conclusions: The waning antibody levels in individuals with AO may further support recent recommendations to offer booster vaccines to adults with high-risk medical conditions including obesity and particularly to those with more prevalent abdominal obesity phenotype.
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