Published January 15, 2022
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ALCOHOL INDUCED OXIDATIVE STRESS IN TESTES OF EXPERIMENTAL ANIMALS
Authors/Creators
- 1. Asst. Professor, Department of Biochemistry, Mahe Institute of Dental Sciences and Hospital, Mahe.
- 2. School of Health Sciences, University of Calicut.
- 3. Asst. Professor, Department of Microbiology, Mahe Institute of Dental Sciences and Hospital, Mahe.
Description
A study was conducted to evaluate the alcohol induced oxidative Stress (OS) in the testes of experimental animals. Albino rats of Wister stain weighing 200-220 g were used for the study. The experimental groups received 1.6 g of ethanol/kg of body weight/day for 12 weeks. It was observed that alcohol used for a long period caused significant OS in the testes as a result of the generation of Super Oxide (SO) radical due to the alcohol metabolism. A significant reduction in glutathione and increased in barbituric acid reactive substances were observed. SO dismutase activity and glutathione reductase activity decreased significantly in the experimental group.
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