Dataset related to article "High prevalence of multidrug-resistant bacteria in patients with pyogenic liver abscess following liver cancer loco-regional treatments"

This record contains raw data related to article “High prevalence of multidrug-resistant bacteria in patients with pyogenic liver abscess following liver cancer loco-regional treatments"

Liver abscess is a rare condition, associated with significant in-hospital mortality. Because of improved diagnostic yield and standardized treatment strategies, mortality has been reduced from 70% to 6% in the last decades.^{1, 2}

The aetiology of pyogenic liver abscess (PLA) varies according to geographical areas and is relevant to tailor treatment strategies; in Western countries, 80% of PLA are bacterial with Escherichia coli, other Enterobacteriaceae and anaerobes being the most common microorganisms. In Asia, Klebsiella pneumoniae has emerged as the most common pathogen in the last two decades, with up to 81.1% of cases reported in Taiwan.^{3, 4} Interestingly, increasing frequencies of PLA from K. pneumonia have also been observed in Europe and the United States.⁵

The most common risk factors for PLA include primary liver tumour and metastases, loco-regional liver procedures and liver cysts.

The treatment of PLA with antibiotic therapy, percutaneous drainage and management of the underlying cause is the current standard of care; however, the recommended antibiotic regimen and the optimal duration of treatment remain uncertain.

Yin et al⁶ reported in a retrospective study the management of 1572 patients with PLA in China. The most identified microorganism was K. pneumoniae (85.6%), with an overall mortality of 4.5% following abscess drainage and antibiotic therapy. Prognosis was associated with length of hospitalization, fever, pleural effusion and development of multiple organ dysfunction.

Given the increase in incidence of multi-drug resistant (MDR) infections in the western world and the differences in aetiology of PLA between geographical areas, we analysed the aetiology and mortality of PLA in our centre, focusing on the prevalence and factors associated with MDR bacterial infections