Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy
- Muscogiuri, Giuseppe1
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Fusini, Laura1
- Ricci, Francesca2
- Sicuso, Rita1
- Guglielmo, Marco1
- Baggiano, Andrea1
- Gasperetti, Alessio3
- Casella, Michela4
- Mushtaq, Saima1
- Conte, Edoardo1
- Annoni, Andrea1
- Formenti, Alberto1
- Mancini, Maria Elisabetta1
- Babbaro, Mario5
- Mollace, Rocco6
- Collevecchio, Ada7
- Scafuri, Stefano8
- Kukavica, Deni9
- Andreini, Daniele1
- Basso, Cristina7
- Rizzo, Stefania7
- De Gaspari, Monica7
- Priori, Silvia9
- Dello Russo, Antonio10
- Tondo, Claudio1
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Pepi, Mauro1
- Sommariva, Elena1
- Rabbat, Mark11
- Guaricci, Andrea Igoren12
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Pontone, Gianluca1
- 1. Centro Cardiologico Monzino IRCCS
- 2. Istituto di radiologia, Fondazione policlinico universitario Agostino gemelli IRCSS Università Cattolica del Sacro Cuore, Rome, Italy
- 3. University Heart Center, University Hospital Zurich, Switzerland.
- 4. Cardiology and Arrhythmology Clinic, Department of Clinical, Special and Dental Sciences, University Hospital "Umberto I - Lancisi - Salesi", Marche Polytechnic University, Ancona, Italy
- 5. Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Italy
- 6. Division of Cardiology, University Hospital Policlinico Tor Vergata, Rome, Italy
- 7. Cardiovascular Pathology, Azienda Ospedaliera, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy
- 8. Interventional Cardiology Unit, Mediterranea Cardiocentro, Naples, Italy
- 9. Department of Molecular Medicine, University of Pavia, Pavia, Italy; IRCCS Istituti Clinici Scientifici Maugeri, Pavia, Italy
- 10. Cardiology and Arrhythmology Clinic, Department of Biomedical Sciences and Public Health, University Hospital "Umberto I - Lancisi - Salesi", Marche Polytechnic University, Ancona, Italy
- 11. Loyola University of Chicago, Chicago, IL, United States of America; Edward Hines Jr. VA Hospital, Hines, IL, United States of America
- 12. Institute of Cardiovascular Disease, Department of Emergency and Organ Transplantation, University Hospital "Policlinico Consorziale" of Bari, Bari, Italy
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This record contains raw data related to the article “Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy”
Abstract
Background: We aim to evaluate the value of Cardiac magnetic resonance (CMR) feature tracking (CMR-FT) in addition to Task Force Criteria(TFC) in patients with (arrhythmogenic cardiomyopathy) AC biopsy-proved.
Methods: Thirty-five patients with AC histologically proven who performed CMR with late gadolinium enhancement (LGE) acquisition were enrolled. The study population was divided in Group1 (negative CMR TFC and LV ejection fraction≥55%) and Group2 (positive CMR TFC and/or LVEF<55%) and compared to an age and gender-matched control group. CMR datasets of all patients were analyzed to calculate LV indexed end-diastolic (LVEDi) and end-systolic (LVESi) volumes and RV indexed end-diastolic (RVEDi) and end-systolic (RVESi) volumes, both LV ejection fraction (LVEF) and RV ejection fraction (RVEF). Moreover, LV and RV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain were measured.
Results: The AC patients showed both higher LVEDi (p:0.002) and RVEDi (p:0.017) and lower LVEF (p: 0.016) as compared to control patients. Moreover, AC patients showed impaired LV-GLS (p < 0.001), LV-GRS (p < 0.001), LV-GCS (p < 0.001) and RV-GRS (p:0.026) as compared to control subjects. Group1 patients showed a significant reduction of LV-GRS (p < 0.05) and LV-GCS p < 0.01) as compared to control subjects. At univariate analysis LV-GCS was the most discriminatory parameter between Group1 vs heathy subjects with an optimal cut-off of -15.8 (Sensitivity: 74%; Specificity: 10%).
Conclusions: In patients with AC biopsy-proven, CMR-FT could improve the diagnostic yield in the subset of patients who results negative for imaging TFC criteria resulting as useful gatekeeper for indication of myocardial biopsy in case of equivocal clinical and imaging presentation.
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- Is supplement to
- Journal article: 10.1016/j.ijcard.2021.06.052 (DOI)