Published January 17, 2022 | Version v1
Dataset Open

Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery

Authors/Creators

  • 1. Enveda Biosciences
  • 2. Bonn-Aachen International Center for IT
  • 3. Barcelona Supercomputing Center

Description

This contains data described in detail in our paper, "Causal reasoning over knowledge graphs leveraging drug-perturbed and disease-specific transcriptomic signatures for drug discovery", where we develop a novel algorithm called RPath that prioritizes drugs for a given disease by reasoning over causal paths in a knowledge graph (KG), guided by both drug-perturbed as well as disease-specific transcriptomic signatures.

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