A convenient and efficient procedure for selective deprotection of acetates by titanium(IV) isopropoxide

Department of Organic Chemistry, Indian Association for the Cultivation of Science, Calcutta-700 032, India

Manuscript received 6 August 1999

A simple and efficient procedure for the deprotection of acetates using titanium(lV) isopropoxide has been demonstrated. A wide range of structurally varied acetates have been subjected to deprotection by this procedure to give the corresponding alcohols m high yields. This procedure offers remarkable selectivity for deprotection of acetate over benzoate, p-nitrobenzoate and allyl, benzyl, TBDMS and THP ethers.