Studies on synthesis and antibacterial activity of some new Schiff bases, 4-thiazolidinones and 2-azetidinones

P. G. Department of Chemistry, Dnyanopasak College, Parbhani-431 401, India

P. G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431 602, India

Manuscript received 13 November 1998, accepted 11 February 1999

Iodovanillin on condensation with different substituted aromatic amines yield Schiff bases (la-e) which on cyclization with mercaptoacetic acid afford the corresponding 4-thiazolidinones (2a-e). Compounds 1a-e on reaction with chloroacetyl chloride and Et₃N in dioxane furnish the respective 2-azetidinones (3a-e). All the compounds have been evaluated for their in vitro growth inhibitory activity against several bacteria.