Synthesis of fused sulfonamide (1,1-dioxoisothiazole)substituted 1,5-diarylpyrazoles as cyclooxygenase inhibitors

Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur,

Hyderabad-500 049, India

E-mail : manojitpal @drreddys.com; koteswarraoy @drreddys.com                    Fax : 91-40-23045438/23045007

Manuscript received 15 October 2003

First synthesis of novel 1,1-dioxo-2,3-dihydrobenzo[d]isothiazolyl substituted 1,5-diarylpyrazoles has been accomplished via oxidative cyclization of 4-nuoro-2-methyl benzenesulfonamide followed by the treatment with hydrazine and then with 1,3- dicarbonyl compounds. A number of 1,5-diarylpyrazoles were synthesized in good yields and some of them were of potential biological interest.