ACAM - Apposed Cortex Adhesion Model
- 1. University of Cambridge
- 2. University of Sheffield
- 3. CNRS - Univ Grenoble Alpes
Description
ACAM: an Apposed-Cortex Adhesion Model of an epithelial tissue.
The ACAM library is an implementation of a mechanical model of an active epithelial tissue. See bioRxiv 10.1101/2021.04.11.439313 for the modelling and results.
How is the cell cortex represented?
Each cell cortex in ACAM is represented as an active, continuum morphoelastic rod with resistance to bending and extension. By explicitly considering both cortices along bicellular junctions, the model is able to replicate important cell behaviours that are not captured in many existing models e.g. cell-cell shearing and material flow around cell vertices.
How are adhesions represented?
Adhesions are modelled as simple springs, explicitly coupling neighbouring cell cortices. Adhesion molecules are given a characteristic timescale, representing the average time between binding and unbinding, which modules tissue dynamics.
Files
acam-1.0.0.zip
Files
(15.9 MB)
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Additional details
Related works
- Is continued by
- Software: https://gricad-gitlab.univ-grenoble-alpes.fr/etiennej/acam (URL)
- Is documented by
- Preprint: 10.1101/2021.04.11.439313 (DOI)
- Is identical to
- Software: https://gricad-gitlab.univ-grenoble-alpes.fr/etiennej/acam/-/releases/1.0.0 (URL)
References
- Nestor-Bergmann et al, Adhesion-regulated junction slippage controls cell intercalation dynamics in an Apposed-Cortex Adhesion Model, PLOS Comput Biol, 2022