Synthesis and biological activity of some 2,4,6-trisubstituted-1,3,5-s-triazines

Department of Chemistry, B. K. M. Science College, Valsad-396 001, India

Manuscript received 11 July 2001, revised 16 September 2002, accepted 28 September 2002

2-[4-( 4-Chlorophenyl)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino]-4,6-dichloro-s-triazine (2), derived from 2-a mino-4-( 4- chlorophenyl)-6-(3,4,5-trimethoxyphenyl)pyrimidine (1) and 2,4,6-trichloro-1 ,3,5-s-triazine, on treatment with morpholine gave 2-14-( 4-chloropheny 1)-6-(3,4,5-trimethoxyphenyl)pyrimidin-2-ylamino}-4-(morpholino)-6-chloro-s-triazi ne (3 ). Compound 3 when reacted with different aryllhioureas in the presence of weak base gave new 2-[4-(4-chlorophenyl)-6-(3,4,5- trimethoxyphenyl)pyrimidin-2-ylaminol-4-(morpholino)-6-(arylthioureido)-s-triazines (4a-j). The compounds were screened for their antibacterial, antifungal and antitubercular activities.