Synthesis of diketopiperazines containing prolinyl unit - cyclo(L-prolinyl-L-leucine), cyclo(L-prolinyl-L-isoleucine) and cyclo(L-tryptophyl-L-proline)

Department of Chemistry, Faculty of Science, University of Mauritius, Réduit, Mauritius
E-mail : sabina@uom.ac.mu                         Fax : 230-4656928
Manuscript received 3 June 2002, revised 10 February 2003, accepted 1 April 2003

Diketopiperazines cyclo(L-prolinyl-L-isoleucine) 4a, cyclo(L-prolinyl-L-Ieucine) 4b and cyclo(L-tryptophyl-L-proline) 6 were
prepared from their respective suitably protected amino acid derivatives by standard peptide chemistry. Cyclo(L-(4-
hydroxyprolinyi)-L-phenylalanine) 3, 4a and cyclo(L-prolinyl-L-tyrosine) 5 were tested for their antibacterial activity.