Synthesis of some new N1-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indole derivatives and their pharmacological activity

Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University,
Sagar-470 003, Madhya Pradesh, India

E-mail : professorsks@rediffmail.com

Manuscript received 17 March 2006, revised 25 July 2006, accepted 7 September 2006

Indole on reaction with chloroacetyl chloride afforded N¹-(1-chloro acetyl)-indole which was renuxed with hydrazine hydrate to give N¹-[(1-hydrazino)acetyl]-indole. The hydrazino derivative of indole was further treated with various substituted aromatic carbonyls to get N¹-[(benzylidene hydrazino)-acetyl]-indoles (3a-j). The compounds 3a-j were treated with chloroacetyl chloride in presence of Et₃N to afford N¹-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)] -indoles,4a-j. The structures of all the compounds were elucidated by elemental analysis, IR and ¹H NMR spectrometry. All the compounds were screened for their antimicrobial, anti-iunammatory and anticonvulsant activities.