An efficient, microwave assisted solvent-free synthesis of polarized enamines

Organic Research Laboratory, Department of Chemistry, St. Anthony's College, Shillong-793 00 I, India
E-mail: jnvishwakarma@rediffmail.com
Manuscript received 14 August 2003, revised 9 March 2004, accepted 6 April 2004

Reactions of acetophenones (1a-e), phenylacetonitrilcs (If-h) and nitromethane (li) with dimethylformamide-dimcthylacetal
were carried out in domestic microwave oven to give 3-dimethylamino-1-arylprop-2-en-1-ones (2a-c), 3-dimethylamino-1-
arylacrylonitriles (2f-h) and 2-dimethylamino-1-nitroethene (2i), respectively, in very good to excellent yields. This methodology
represents an ceo-friendly green approach to these valuable synthons and has the advantage of involving shorter reaction
times, solvent-less conditions and higher yields.