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Published April 25, 2016 | Version v1
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Basic Physicochemical Properties of Polyethylene Glycol Coated Gold Nanoparticles that Determine Their Interaction with Cells

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Description

A homologous nanoparticle library was synthesized in which gold nanoparticles were coated with polyethylene glycol, whereby the diameter of the gold cores, as well as the thickness of the shell of polyethylene glycol, was varied. Basic physicochemical parameters of this two-dimensional nanoparticle library, such as size, ?-potential, hydrophilicity, elasticity, and catalytic activity,were determined. Cell uptake of selected nanoparticles with equal size yet varying thickness of the polymer shell and their effect on basic structural and functional cell parameters was determined. Data indicates that thinner, more hydrophilic coatings, combined with the partial functionalization with quaternary ammonium cations, result in a more efficient uptake, which relates to significant effects on structural and functional cell parameters. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Notes

Parts of this work were supported by the European Commission (project FutureNanoNeeds, grant to WJP), and by the MINECO (project MAT2013-48169-R to WJP and PdP). BP acknowledges a postdoctoral fellowship from the Alexander von Humboldt Foundation. QZ acknowledges a graduate student fellowship for the Chinese Scholarship Council (CSC). SJS is a post-doctoral fellow from the FWO Vlaanderen. BBM acknowledges the FWO Vlaanderen (Krediet aan Navorsers 1514716N).

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European Commission
FUTURENANONEEDS - Framework to respond to regulatory needs of future nanomaterials and markets 604602