The synthesis of Sintenin, a new cytotoxic ester from Piper sintenense

Department of Chemistry, Panjab University, Chandigarh-160 014, India
E-mail: sdsharmapu@yahoo.com Fax: 91-172-2545074
Manuscript received 3 November 2004, revised 19 May 2005, accepted 2 July 2005

A first short synthesis of Sintenin 1 has been accomplished starting from 3,4-dimethoxybenzaldehyde 2 utilizing Knoevenagal condensation and catalytic hydrogenation using Pd/C as key reactions, in almost quantitative yield. The identity with the naturally occurring compound Sintenin was established on the basis of ¹H NMR and ¹³C NMR data.