TOGETHER - Connecting people and systems to support an effective psychosocial adjustment to genetic testing in the context of inherited cancer risk - Scientific contributions

There is a newer version of the record available.

Published January 6, 2022 | Version v1
Preprint Open

The Genetic Psychosocial Risk Instrument (GPRI): A Validation Study for Hereditary Cancer Risk

Authors/Creators

  • 1. Cancer Genetics Group, Research Centre of IPO Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Centre (Porto.CCC). & Faculty of Psychology and Education Sciences (FPCEUP), Centre for Psychology at University of Porto (CPUP), University of Porto, Portugal
  • 2. Faculty of Psychology and Education Sciences (FPCEUP), Centre for Psychology at University of Porto (CPUP), University of Porto, Portugal & Cancer Genetics Group, Research Centre of IPO Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Centre (Porto.CCC)
  • 3. Cancer Genetics Group, Research Centre of IPO Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Centre (Porto.CCC). & Psychology Service, Research Centre, Portuguese Oncology Institute of Porto, Porto, Portugal
  • 4. Cancer Genetics Group, Research Centre of IPO Porto (CI-IPOP) / RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO Porto) / Porto Comprehensive Cancer Centre (Porto.CCC). & Department of Genetics, Portuguese Oncology Institute of Porto, Porto, Portugal
  • 5. Department of Psychiatry, Termerty Faculty of Medicine, University of Toronto

Description

Abstract

 Purpose: Screening instruments specifically developed to identify genetic testing applicants who may need professional psychosocial support are much needed. However, there are none validated for the Portuguese population. This paper presents the translation, adaptation, and validation process of the Genetic Psychosocial Risk Instrument (GPRI) in a sample of 207 Portuguese applicants to genetic testing in the context of inherited cancer risk.

Methods: Participants were mainly female (84.06%), with a mean age of 40.08 (SD = 12.89) and were recruited from the Portuguese Oncology Institute of Porto (IPO-PORTO). Confirmatory Factor Analysis was conducted to study the GPRI factorial structure. Convergent validity was assessed with the Impact of Events Scale (IES), the Clinical Outcome Routine Evaluation – Outcome Measure (CORE-OM), and the Hospital Anxiety and Depression Scale (HADS).

Results: It was confirmed a model composed by the factors Internal Impact of Genetic Testing, External Impact of Genetic Testing and History of Mental Health Concerns. These factors showed good internal consistency, convergent and discriminant validity. The factor Personal Loss to Cancer proposed in prior versions did not converge. We propose excluding this factor from the Portuguese Version of the scale.

Conclusion: The Portuguese version of the GPRI is a reliable and valid instrument to use in routine clinical oncogenetic services as well as research settings.

Notes

This work was supported by the European COMPETE2020 [grant number POCI-01-0145-FEDER-030980] and Portuguese National funds FCT - Fundação para a Ciência e a Tecnologia, I.P [grant number PTDC/PSI-ESP/30980/2017].

Files

Gomes et al - Validation of GPRI_Preprint.pdf

Files (294.9 kB)

Name Size Download all
md5:44a8209499d458ae3f3b8fa11ae089f5
294.9 kB Preview Download