Published June 15, 2015 | Version v1
Journal article Open

METABOLIC AND HAEMATOLOGICAL PARAMETERS IN PARETIC COWS THAT RECEIVED OR NOT RECEIVED KETOPROFEN (Case report)

Authors/Creators

  • 1. University of Novi Sad, Faculty of Agriculture

Description

In the period after calving in cows there are many endocrin and metabolic changes because of the increase in energy demand which can cause numerous diseases including puerperal paresis, which is caused by hypocalcemia. The aim of this study was to compare the metabolic and hematological parameters in the first and second week after calving in paretic cows which is administered ketoprofen during three days after calving. Blood samples were taken from cows with postpartum paresis 7 and 14 days after calving. We examined the blood count (number of leukocytes, neutrophils, lymphocytes, red blood cells and hemoglobin concentration) and metabolic profile of cows (total protein, albumin, bilirubin, Ca, P, glucose, hoelsterol, AST, GGT, NEFA, BHB). Application ketoprofen does not lead to significant differences in the absolute values of the parameters. However, there was a significant difference in the dynamic changes in the blood picture and metabolism in the second week after birth compared to the first, so that cows that received ketoprofen have less lipid mobilization and ketogenesis, less load hepatocytes and favorable ratio of neutrophils and lymphocytes. We conclude that the use of ketoprofen may be useful as a form of supportive therapy, as it reduces the intensity of lipid mobilization and ketogenezis, and relieves the symptoms of inflammatory response and liver dysfunction in paretic cows.

Files

18. Kovacevic et al..pdf

Files (405.0 kB)

Name Size Download all
md5:993d104ebc1c940332d39763f579fbe5
405.0 kB Preview Download

Additional details

References

  • BERNABUCCI, U., RONCHI, B., LACETERA N. AND NARDONE, A.: Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. J. Dairy Sci., 88(6)2017-2026. 2005.
  • BERNABUCCI, U., BASIRICÒ, L., PIRAZZI, D., RUECA, F., LACETERA, N., LEPRI, E., NARDONE, A.: Liver apolipoprotein B100 expression and secretion are down-regulated early postpartum in dairy cows. Livestock Science, 125(2/3) 169-176, 2009.
  • CALDER, P.C.: The relationship between the fatty acid composition of immune cells and their function. Prostaglandins, Leukotrienes and Essential Fatty Acids. 79:101–108. 2008.
  • DAVIS A.K., MANEY, D.L., MAERZ, J.C.: The use of leukocyte profiles to measure stress in vertebrates: a review for ecologists. Functional Ecology, 22:760–772, 2008.
  • DONALISIO, C., BARBERO, R., CUNIBERTI, B., VERCELLI, C., CASALONE, M. RE. G.: Effects of flunixin meglumine and ketoprofen on mediator production in ex vivo and in vitro models of inflammation in healthy dairy cows. Journal of Veterinary Pharmacology and Tharapeutics, 36(2)130.-139, 2013.
  • DIVERS, T.J., PEEK, S.F.C: Rebhuns diseases of dairy cattle, Saunders, Elsevier, St.Louis, Missouri, 2008.
  • DOUGLAS, G.N., REHAGE, J., BEAULIEU, A.D., BAHAA, A.O. AND DRACKLEY, J.K.: Prepartum nutrition alters fatty acid composition in plasma, adipose tissue, and liver lipids of periparturient dairy cows. Journal of Dairy Science, 90:2941–2959, 2007.
  • DRACKLEY, J.K.: Biology of dairy cows during the transition period: the final frontier? Journal of Dairy Science, 82(11)2259–2273, 1999.
  • ĐOKIĆ S., CINCOVIĆ M.R., BELIĆ B., RADINOVIĆ M., STOJANOVIĆ D., ĐOKOVIĆ R.: Laboratorijski nalaz kod sindroma ležećih krava. Letopis naučnih radova Poljoprivrednog fakulteta, 38 (1)190-199, 2014.
  • ĐOKOVIĆ, R.D.: Endokrini status mlečnih krava u peripartalnom periodu. Agronomski fakultet, Čačak, 2010.
  • ĐOKOVIĆ, R.D., CINCOVIĆ M.R., BELIĆ B.M.: Fiziologija I patofiziologija metabolizma krava u peripartalnom period. Poljoprivredni fakultet Novi Sad, 2014.
  • GIESY, S. L., YOON, B., CURRIE, W. B., KIM, J. W., BOISCLAIR, Y. R.: Adiponectin deficit during the precarious glucose economy of early lactation in dairy cows. Endocrinology, 153:5834-5844, 2012.
  • GOFF, J.P.: Macromineral physiology and application to the feeding of the dairy cow for prevention of milk fever and other periparturient mineral disorders. Animal Feed Science and Technology, 126(3-4)237–257, 2006.
  • HAYIRLI, A.: The role of exogenous insulin in the complex of hepatic lipidosis and ketosis associated with insulin resistance phenomenon in postpartum dairy cattle. Vet. Res. Commun., 30:749-774, 2006.
  • HARDARDOTTIR, I., GRUNFELD, C. AND FEINGOLD, K. R.: Effects of endotoxin and cytokines on lipid metabolism. Curr. Opin. Lipid. 5:207-215, 1994.
  • INGVARTSEN, K. L.: Feeding- and management-related diseases in the transition cow. Anim. Feed Sci. Technol., 126:175-213, 2006.
  • KUSHIBIKI, S., HODATE, K., SHINGU, H., UEDA, Y., MORI, Y., ITOH, T. AND YOKOMIZO, Y.: Effects of long-term administration of recombinant bovine tumor necrosis factor-alpha on glucose metabolism and growth hormone secretion in steers. Am. J. Vet. Res., 62:794-798, 2001.
  • KOVACEVIC FILIPOVIC, M.: Osobenosti krvne slike goveda tokom njihovog rasta i razvoja. Zbornik Poremećaj zdravlja krava u puerperijumu i zdravstveni status teladi, 85-100, 2007.
  • LATIMER, K.S., PRASSE, K.W.: Leukocytes. In: Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology. 4th ed. Ames, IA: Iowa State Press, 46–79, 2003.
  • LEES, P., LANDONI, M.F., GIRAUDEL, J., TOUTAIN, P.L.: Pharmacodynamics and pharmacokinetics of nonsteroidal anti-inflammatory drugs in species of veterinary interest. Journal of veterinary pharmacology and therapeutics 27, 479-490, 2004.
  • LYNCH, E.M., EARLEY, B., MCGEE, M., DOYLE, S.: Characterisation of physiological and immunological responses in beef cowsto abrupt weaning and subsequent housing. BMC Veterinary Research, 6:37, 2010.
  • SERHAN, C. N., CHIANG, N. AND VAN DYKE, T. E.: Resolving inflammation: dual antiinflammatory and pro-resolution lipid mediators. Nat. Rev. Immunol., 8: 349-361. 2008.
  • SAMANC, H.A.: Bolesti organa za varenje goveda. Beograd, 2009.
  • TORNQUIST, S.J., RIGAS, J.: Interpretation of Ruminant Leukocyte Responses. In: Schalms veterinary hematology. 6th edition, Wiel-Blackwell, 307-313, 2010.
  • TREVISI, E., CALAMARI, L. & BERTONI, G.: Definition of a liver activity index in the transition dairy cow and its relationship with the reproductive performance. Proc. X Int. Symp. of Veterinary Laboratory Diagnosticians, 4-7 July, Salsomaggiore-Parma, Italy, 118-119, 2001.
  • TREVISI, E. M. AMADORI, A. M. BAKUDILA AND BERTONI, G.: Metabolic changes in dairy cows induced by oral, low-dose interferon-alpha treatment. J. Anim Sci., 87(9):3020-3029, 2009.
  • TREVISI E., ZECCONI A., BERTONI G. & PICCININI R.: Blood and milk immune and inflammatory responses in periparturient dairy cows showing a different liver activity index. Journal of Dairy Research, 77:310-317, ISSN: 0022-0299, 2010.